braas
Pituitary Adenylate Cyclase-activating Polypeptides Directly Stimulate Sympathetic Neuron Neuropeptide Y Release through PAC1 Receptor Isoform Activation of Specific Intracellular Signaling Pathways -- Braas and May 274 (39): 27702 -- Journal of Biological Chemistry
HOME
HELP
FEEDBACK
SUBSCRIPTIONS
ARCHIVE
SEARCH
TABLE OF CONTENTS
QUICK SEARCH:
[advanced]
Author:
Keyword(s):
Year:
Vol:
Page:
This Article
Full Text
Full Text (PDF)
Alert me when this article is cited
Alert me if a correction is posted
Citation Map
Services
Email this article to a friend
Similar articles in this journal
Similar articles in PubMed
Alert me to new issues of the journal
Download to citation manager
Citing Articles
Citing Articles via HighWire
Citing Articles via Google Scholar
Google Scholar
Articles by Braas, K. M.
Articles by May, V.
Search for Related Content
PubMed
PubMed Citation
Articles by Braas, K. M.
Articles by May, V.
J Biol Chem, Vol. 274, Issue 39, 27702-27710, September 24, 1999
Pituitary Adenylate Cyclase-activating Polypeptides Directly
Stimulate Sympathetic Neuron Neuropeptide Y Release through
PAC1 Receptor Isoform Activation of Specific Intracellular
Signaling Pathways
Karen M.
Braas and
Victor
May
From the Department of Anatomy and Neurobiology, College of
Medicine, University of Vermont, Burlington, Vermont 05405
Pituitary adenylate cyclase-activating
polypeptides (PACAP) have potent regulatory and neurotrophic activities
on superior cervical ganglion (SCG) sympathetic neurons with
pharmacological profiles consistent for the PACAP-selective
PAC1 receptor. Multiple PAC1 receptor
isoforms are suggested to determine differential peptide potency and
receptor coupling to multiple intracellular signaling pathways. The
current studies examined rat SCG PAC1 receptor splice
variant expression and coupling to intracellular signaling pathways
mediating PACAP-stimulated peptide release. PAC1 receptor
mRNA was localized in over 90% of SCG neurons, which correlated
with the cells expressing receptor protein. The neurons expressed the
PAC1(short)HOP1 receptor but not
VIP/PACAP-nonselective VPAC1 receptors; low
VPAC2 receptor mRNA levels were restricted to
ganglionic nonneuronal cells. PACAP27 and PACAP38 potently and
efficaciously stimulated both cAMP and inositol phosphate production;
inhibition of phospholipase C augmented PACAP-stimulated cAMP
production, but inhibition of adenylyl cyclase did not alter stimulated
inositol phosphate production. Phospholipase C inhibition blunted
neuron peptide release, suggesting that the phosphatidylinositol pathway was a prominent component of the secretory response. These studies demonstrate preferential sympathetic neuron expression of
PACAP-selective receptor variants contributing to regulation of
autonomic function.
Copyright © 1999 by The American Society for Biochemistry and Molecular Biology, Inc.
This article has been cited by other articles:
T. Mustafa, M. Grimaldi, and L. E. Eiden
The Hop Cassette of the PAC1 Receptor Confers Coupling to Ca2+ Elevation Required for Pituitary Adenylate Cyclase-activating Polypeptide-evoked Neurosecretion
J. Biol. Chem.,
March 16, 2007;
282(11):
8079 - 8091.
[Abstract]
[Full Text]
[PDF]
K. M. Braas, V. May, P. Zvara, B. Nausch, J. Kliment, J. D. Dunleavy, M. T. Nelson, and M. A. Vizzard
Role for pituitary adenylate cyclase activating polypeptide in cystitis-induced plasticity of micturition reflexes
Am J Physiol Regulatory Integrative Comp Physiol,
April 1, 2006;
290(4):
R951 - R962.
[Abstract]
[Full Text]
[PDF]
S. L. Gray, N. Yamaguchi, P. Vencova, and N. M. Sherwood
Temperature-Sensitive Phenotype in Mice Lacking Pituitary Adenylate Cyclase-Activating Polypeptide
Endocrinology,
October 1, 2002;
143(10):
3946 - 3954.
[Abstract]
[Full Text]
[PDF]
V. May, M. R. Schiller, B. A. Eipper, and R. E. Mains
Kalirin Dbl-Homology Guanine Nucleotide Exchange Factor 1 Domain Initiates New Axon Outgrowths via RhoG-Mediated Mechanisms
J. Neurosci.,
August 15, 2002;
22(16):
6980 - 6990.
[Abstract]
[Full Text]
[PDF]
K. Drahushuk, T. D. Connell, and D. Higgins
Pituitary Adenylate Cyclase-Activating Polypeptide and Vasoactive Intestinal Peptide Inhibit Dendritic Growth in Cultured Sympathetic Neurons
J. Neurosci.,
August 1, 2002;
22(15):
6560 - 6569.
[Abstract]
[Full Text]
[PDF]
M. S. Silveira, M. R. Costa, M. Bozza, and R. Linden
Pituitary Adenylyl Cyclase-activating Polypeptide Prevents Induced Cell Death in Retinal Tissue through Activation of Cyclic AMP-dependent Protein Kinase
J. Biol. Chem.,
May 3, 2002;
277(18):
16075 - 16080.
[Abstract]
[Full Text]
[PDF]
S. Boehm and H. Kubista
Fine Tuning of Sympathetic Transmitter Release via Ionotropic and Metabotropic Presynaptic Receptors
Pharmacol. Rev.,
March 1, 2002;
54(1):
43 - 99.
[Abstract]
[Full Text]
[PDF]
D. E. Hansel, V. May, B. A. Eipper, and G. V. Ronnett
Pituitary Adenylyl Cyclase-Activating Peptides and {alpha}-Amidation in Olfactory Neurogenesis and Neuronal Survival In Vitro
J. Neurosci.,
July 1, 2001;
21(13):
4625 - 4636.
[Abstract]
[Full Text]
[PDF]
A. Nicot and E. DiCicco-Bloom
Regulation of neuroblast mitosis is determined by PACAP receptor isoform expression
PNAS,
April 10, 2001;
98(8):
4758 - 4763.
[Abstract]
[Full Text]
[PDF]
K. Pavelock, K. M. Braas, L'H. Ouafik, G. Osol, and V. May
Differential Expression and Regulation of the Vascular Endothelial Growth Factor Receptors Neuropilin-1 and Neuropilin-2 in Rat Uterus
Endocrinology,
February 1, 2001;
142(2):
613 - 622.
[Abstract]
[Full Text]
[PDF]
R. E. ZIGMOND
Neuropeptide Action in Sympathetic Ganglia: Evidence for Distinct Functions in Intact and Axotomized Ganglia
Ann. N.Y. Acad. Sci.,
December 1, 2000;
921(1):
103 - 108.
[Full Text]
[PDF]
V. MAY, M. M. BEAUDET, R. L. PARSONS, and K. M. BRAAS
PACAP Modulates Rat Sympathetic Neuron Depolarization Through IP3
Ann. N.Y. Acad. Sci.,
December 1, 2000;
921(1):
186 - 194.
[Full Text]
[PDF]
R. L. PARSONS, T. M. ROSSIGNOL, M. A. CALUPCA, J. C. HARDWICK, and K. M. BRAAS
PACAP Peptides Modulate Guinea Pig Cardiac Neuron Membrane Excitability and Neuropeptide Expression
Ann. N.Y. Acad. Sci.,
December 1, 2000;
921(1):
202 - 210.
[Abstract]
[Full Text]
[PDF]
M. M. Beaudet, R. L. Parsons, K. M. Braas, and V. May
Mechanisms Mediating Pituitary Adenylate Cyclase-Activating Polypeptide Depolarization of Rat Sympathetic Neurons
J. Neurosci.,
October 1, 2000;
20(19):
7353 - 7361.
[Abstract]
[Full Text]
[PDF]
D. Vaudry, B. J. Gonzalez, M. Basille, L. Yon, A. Fournier, and H. Vaudry
Pituitary Adenylate Cyclase-Activating Polypeptide and Its Receptors: From Structure to Functions
Pharmacol. Rev.,
June 1, 2000;
52(2):
269 - 324.
[Abstract]
[Full Text]
[PDF]
HOME
HELP
FEEDBACK
SUBSCRIPTIONS
ARCHIVE
SEARCH
TABLE OF CONTENTS
All ASBMB Journals
Molecular and Cellular Proteomics
Journal of Lipid Research
ASBMB Today
Copyright © 1999 by the American Society for Biochemistry and Molecular Biology.
разделы
dhl
кс-4361
диагностический стенд
промышленый альпинизм
лечение иглоукалыванием
два цвет
ночной очки
nokia 3230 купить
braas